The NeuroHormone Complete Plus Profile combines the Comprehensive Plus Hormone Profile and the Neurobasic Profile. The Comprehensive Plus Profile expands on the Comprehensive Profile and includes estrone (E1), estriol (E3), and the Estrogen Quotient (EQ). Henry Lemon MD developed the Estrogen Quotient, a simple ratio of the cancer protective E3 relative to the proliferative estrogens E1 and E2, to assess breast cancer risk. A lower number (<1.0) indicates increased risk, and a higher number (>1.0) signifies lower risk. Dr. Lemon stated that for maximum protection, an optimal EQ is >1.5. This information may be extrapolated to provide information on other estrogen driven disorders. Because the research on the EQ focused on women, no reference range has been established for males, however some health care providers appreciate the information the additional estrogens provide in relation to prostate health. 
Urinary neurotransmitter levels provide an overall assessment of the body's ability to make and break down neurotransmitters and are representative of whole body levels. Neurotransmitters are secreted all through the body, in neurons of both the central and peripheral nervous systems, as well as the gastrointestinal microbiome. The enzymes, cofactors and precursors in neurotransmitter metabolism in general are the same in the periphery and in the central nervous system. Therefore abnormal levels of neurotransmitters in urine may provide important clinical information, and may be associated with many symptoms including cognitive and mood concerns, diminished drive, fatigue and sleep difficulties, cravings, addictions and pain, and abnormal abundance and diversity within the gastrointestinal microbiome.
Useful for:
Increased risk of developing breast cancer 
History of breast cancer or other hormonally sensitive cancers 
Personal or family history of autoimmune disease 
PCOS 
Mood concerns, such as depression, anxiety
Diminished energy/fatigue
Insomnia
Cognitive concerns such as forgetfulness, inattention, brain fog
Addiction, dependency
Obsessions and cravings
Chronic illness, immune deficiency
Pain
Low libido, sexual dysfunction