The Comprehensive Plus Profile expands on the Comprehensive Profile and includes estrone (E1), estriol (E3), and the Estrogen Quotient (EQ). Henry Lemon MD developed the Estrogen Quotient, a simple ratio of the cancer protective E3 relative to the proliferative estrogens E1 and E2, to assess breast cancer risk. A lower number (<1.0) indicates increased risk, and a higher number (>1.0) signifies lower risk. Dr. Lemon stated that for maximum protection, an optimal EQ is >1.5. This information may be extrapolated to provide information on other estrogen driven disorders. Because the research on the EQ focused on women, no reference range has been established for males, however some health care providers appreciate the information the additional estrogens provide in relation to prostate health.  
Useful for:
Research indicates this profile could be considered for those with increased risk of developing breast cancer, or history of breast cancer or other hormonally sensitive cancers
Personal or family history of autoimmune disease
PCOS