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ADHS® (Biotics Research)

The term "stress" has become synonymous with the American way of life. Our society is often described as "stressed out." This concept, now deeply embedded in our daily vocabulary, was coined over seventy years ago by Hans Selye. He defined stress as nonspecific bodily changes in response to harmful stimuli. Selye also noted that while the adrenal glands are quick to respond to stress, they are also prone to failure under prolonged stressful conditions.

The human body has a sophisticated system for adapting to stress. Survival depends on maintaining internal stability (homeostasis), which is achieved through the activation of the stress response system. This activation leads to both behavioral changes and physiological adjustments.

The adrenal glands, located above each kidney, play a crucial role in managing stress. They are vital for sustaining life, energy production, and regulating the conversion of carbohydrates, proteins, and fats into glucose. Additionally, they influence fluid balance, electrolytes, blood circulation, and even contribute to sex hormone production, particularly post-menopause.

The adrenal cortex secretes four major groups of hormones: glucocorticoids, mineralocorticoids, androgens, and estrogens. The adrenal medulla, on the other hand, produces catecholamines, such as epinephrine and norepinephrine. These hormones, including cortisol (a glucocorticoid), are regulated by pituitary adrenocorticotropic hormone (ACTH) through a feedback mechanism. Cortisol, for instance, affects metabolism, immune responses, and influences blood pressure, glucose levels, and protein synthesis.

Disruptions in the stress response system or maladaptive hormonal responses can lead to various health issues, including growth disturbances, psychiatric disorders, and metabolic imbalances. Chronic stress-induced hypercortisolism has been linked to increased mortality rates and reduced life expectancy. Conditions like Cushing's disease can result from unchecked ACTH hypersecretion, while excess adrenal androgens may contribute to disorders like polycystic ovarian syndrome (PCOS).

Amino Acids for Adrenal Support


A vital amino acid that becomes essential under certain conditions is L-Tyrosine. It serves as a building block for the synthesis of hormones like epinephrine (adrenaline), norepinephrine (noradrenaline), and dopamine, as well as thyroid hormones such as thyroxine (T4) and triiodothyronine (T3). During periods of stress, the body releases more of these substances, which can deplete their levels.

Vitamins for Adrenal Support

Vitamin C:

The adrenal glands have a high concentration of vitamin C, about 100 times more than in the blood. This makes them very sensitive to a lack of vitamin C. Vitamin C helps make certain stress-related hormones. When the body is stressed, the adrenal glands release more vitamin C along with cortisol. Factors like stress, fever, infections, smoking, and drinking alcohol can lower vitamin C levels quickly. People under stress often need more vitamin C.

Thiamin (B1):

Thiamin, as a coenzyme, is crucial for glucose metabolism inside cells, which is important for adrenal function because blood sugar fluctuations are a symptom of adrenal issues. It helps metabolize carbohydrates and is vital for energy production. A lack of thiamin can slow down or block these processes, affecting multiple enzymes, particularly those involved in carbohydrate metabolism.

Riboflavin (B2):

Riboflavin is a key part of the coenzymes FAD and FMN. These are necessary for energy production and red blood cell formation. Adrenal and thyroid problems can impair riboflavin conversion. A deficiency can increase oxidative stress and affect energy transfer, metabolism, antibody production, and growth hormone regulation.

Niacin (B3):

Niacin is essential for the coenzymes NAD and NADP, crucial for energy production and DNA repair. It's important for insulin response and helps manage hypoglycemic symptoms associated with adrenal issues. A lack of niacin can lead to skin changes and nervous system problems.

Pantothenic Acid (B5):

Pantothenic acid is important for metabolizing carbohydrates, fats, and proteins. It's essential for neurotransmitter production and energy cycles. Its deficiency can lead to adrenal gland problems and difficulties handling stress, hence it's sometimes called the "anti-stress" vitamin.

Vitamin B6:

Vitamin B6 acts as a coenzyme in over 100 reactions related to metabolism and health. It supports lipid metabolism and energy production, and its deficiency can lead to decreased mental sharpness, which is common in adrenal dysfunction. It also helps convert tryptophan to niacin and serotonin, and tyrosine to dopamine, which are crucial for adrenal hormone production.

Vitamin E:

Vitamin E (d-alpha tocopheryl acetate) functions primarily as an antioxidant in cells throughout the body, including adrenal cells. Vitamin E supplementation has been shown to reduce lipid peroxidation during periods of stress, protecting liver and brain tissues and maintaining glutathione (strong antioxidant) levels depleted by stress.

Minerals for Adrenal Support


Zinc is essential for enzyme function and adrenal health. A deficiency can affect enzyme activity and increase stress responses. Supplementing zinc can improve adrenal function and reduce stress-related damage.


Manganese is a component of mitochondrial enzymes that protect cells from oxidative stress. It's crucial for carbohydrate, amino acid, and cholesterol metabolism. Manganese deficiency can impair these functions and increase stress.


Copper plays a role in oxidation-reduction reactions and is a component of enzymes involved in cellular energy production. It's vital for adrenal support and overall health.

Lithium & Rubidium:

Lithium and Rubidium, in trace amounts, have relaxant effects and protect against toxicity, benefiting adrenal function.

Botanicals for Adrenal Support

Several botanical extracts are recognized for their ability to balance various adrenal functions without disrupting normal bodily processes. These extracts, originating from Chinese or Ayurvedic traditions, contribute to maintaining healthy adrenal activity.

Achyranthes (root extract):

According to Chinese medicine, Achyranthes invigorates blood circulation and alleviates blood stasis. It is commonly used in formulations that tonify Yang energy, directing the action of other herbs towards the kidneys, genitals, and legs.

Damiana (herb extract):

Found predominantly in Mexico, Southern, and Central America, Damiana is noted for its aromatic leaves and is similarly classified as a Yang tonic. It supports energy levels and strengthens the nervous system, serving traditionally as a nerve stimulant, diuretic, aphrodisiac, and addressing issues such as impotence in men and frigidity in women.

Gotu Kola (herb extract):

In Ayurvedic medicine, Gotu Kola is revered for rejuvenating nerves and brain cells. Its properties include mild antibacterial, antiviral, anti-inflammatory, and anti-ulcerogenic effects. It acts as a cerebral tonic, circulatory stimulant, diuretic, nervine, and vulnerary, with demonstrated immunostimulating activity on cellular and humoral immune responses.

Sichuan Teasel (root extract):

From Chinese tradition, Sichuan Teasel tonifies the liver and kidneys and promotes blood circulation. Its root's crude polysaccharide fraction stimulates lymphocyte mitogenic activity and suppresses macrophage phagocytic activity. Additionally, it exhibits antinociceptive effects in a dose-dependent manner.

Asiatic Dogwood (fruit extract):

Popular in traditional medicine, Asiatic Dogwood is known for its tonic, analgesic, and diuretic properties. It tonifies liver and kidney deficiencies, alleviating symptoms like lightheadedness and dizziness, and supports overall vitality.

Basil (leaf extract):

Widely used in culinary and medicinal contexts across Thailand, India, and Turkey, Basil affects lung and stomach meridians and stimulates the adrenal cortex. Its key compounds include eugenol, citral, geraniol, and rosmarinic acid, which inhibit complement-dependent inflammatory processes.

Schisandra (fruit extract):

Employed in Traditional Chinese Medicine for millennia, Schisandra serves as both a tonic and sedative, enhancing mental functions and supporting stress resistance. It boosts energy levels, enhances endurance, improves vision, muscular strength, and immune function. Modern research also suggests protective effects on the liver and immune modulation properties.

Tinospora cordifolia (stem & root extract):

Known in Ayurvedic medicine for addressing debility, fever, and dyspepsia, Tinospora cordifolia's root exhibits anti-stress and immune-supporting properties. An aqueous extract has shown benefits in adrenaline-induced hyperglycemia.


Stress is a big part of American life today, and the concept of stress was first described over seventy years ago by Hans Selye. He noted that stress causes specific changes in the body, especially affecting the adrenal glands, which are the first to react and the first to fail under stress.

The adrenal glands, located on top of the kidneys, play a key role in stress management, energy production, and the regulation of blood glucose, fluid balance, and sex hormones. They produce several important hormones, including cortisol and adrenaline, which help the body adapt to stress.

Nutritional support is crucial for maintaining healthy adrenal function. Stress increases the body's need for various nutrients. Key vitamins and minerals that support the adrenal glands include Vitamin C, B vitamins (especially B6 and B5), vitamin E, thiamin, riboflavin, niacin, zinc, copper, manganese, and certain amino acids like L-tyrosine.

Additionally, botanicals such as Rhodiola rosea, Gotu Kola, and Schisandra chinensis help support adrenal health and stress resilience. Proper nutrition and supplements can help the adrenal glands function properly, especially during stressful times.

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